Nampt-IN-7

Nampt-IN-7 (compound GF8) is a potent NAMPT inhibitor, with an IC50 of 7.31 μM. Nampt-IN-7 also displays cytotoxic activity against human HepG2 hepatocellular carcinoma cell line with an IC50 of 24.28 μM[1].

Product Specifications

CAS Number

[1223378-42-4]

UNSPSC

12352005

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nampt-in-7.html

Solubility

10 mM in DMSO

Smiles

CCOC(C1=CC=C(C=C1)NC(NCC2=CC(N3C=CN=C3C)=NC=C2)=O)=O

Molecular Formula

C20H21N5O3

Molecular Weight

379.41

References & Citations

[1]Ozgencil F, et al. Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening. Bioorg Med Chem. 2020 Jan 1;28 (1) :115217.