APJ receptor agonist 6

APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1].

Product Specifications

CAS Number

[1965244-85-2]

UNSPSC

12352005

Target

Apelin Receptor (APJ) ; Arrestin

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/apj-receptor-agonist-6.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=CC(OC)=C1C2=CC(C(N[C@H](CC(O)=O)CCC3CCCCC3)=O)=NN2C4=CC=C(C=C4)F

Molecular Formula

C29H34FN3O5

Molecular Weight

523.60

References & Citations

[1]Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28 (4) :115237.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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