SMO-IN-1
SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh) [1].
Product Specifications
CAS Number
1126365-66-9
UNSPSC
12352005
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smo-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1NC(C2=CC=C(C=C2)OCC3=NC=CC=C3)=O)C4=CN(C=N4)C
Molecular Formula
C24H22N4O2
Molecular Weight
398.46
References & Citations
[1]Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5- (1-methylimidazol-4-yl) phenyl]-4- (2-pyridylmethoxy) benzamide (AZD8542) and N-[5- (1H-imidazol-2-yl) -2,4-dimethyl-phenyl]-4- (2- pyridylmethoxy) benzamide (AZD7254) . Bioorg Med Chem. 2020 Jan 15;28 (2) :115227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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