DPPY

DPPY (compound 6) is a potent PTK inhibitor with IC50 values of [1].

Product Specifications

CAS Number

[2095883-62-6]

UNSPSC

12352005

Target

Btk; EGFR; JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dppy.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC(NC2=NC(NC3=CC=C(C=C3)NC(CN4CCOCC4)=O)=NC=C2Cl)=CC=C1)=O

Molecular Formula

C25H26ClN7O3

Molecular Weight

507.97

References & Citations

[1]Zhu Y, et al. Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis. Bioorg Med Chem. 2020 Jan 15;28 (2) :115254.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1; JAK3

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