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GABAA receptor agonist 2

GABAA receptor agonist 2 (compound 4c) is a potent GABAA receptor agonist. GABAA receptor agonist 2 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 2 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 2 has the potential for the research of depression[1].

Product Specifications

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gabaa-receptor-agonist-2.html

Solubility

10 mM in DMSO

Smiles

C[C@]12CC[C@@H](O3)[C@@]3(C)CC[C@@H](OC(C)=O)[C@@]4(C)CC[C@](C(C)C)(O4)C[C@@H]1O2

Molecular Formula

C22H36O5

Molecular Weight

380.52

References & Citations

[1]Ur Rehman N, et al. Incensole derivatives from frankincense: Isolation, enhancement, synthetic modification, and a plausible mechanism of their anti-depression activity. Bioorg Chem. 2022 Sep;126:105900.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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