HDAC6-IN-8
A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.
Product Specifications
CAS Number
[2796282-49-8]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C2N=CN=C(C2=C1)NC3=CC(F)=C(C=C3)Br)CC4=CC=C(C=C4)C(NO)=O
Molecular Formula
C23H17BrFN5O3
Molecular Weight
510.32
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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