Microtubule inhibitor 7
Product Specifications
UNSPSC Description
Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(/C=C2NC(/C(NC\2=O)=C/C3=CC=C(O3)COC)=O)=C1)C4=CC=C(C=C4)F
Molecular Weight
446.43
References & Citations
[1]Ding Z,et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147728/Microtubule-inhibitor-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147728/
Clinical Information
No Development Reported
CAS Number
2416338-65-1
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