Microtubule inhibitor 7

Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

Product Specifications

CAS Number

[2416338-65-1]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/microtubule-inhibitor-7.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC(/C=C2NC(/C(NC\2=O)=C/C3=CC=C(O3)COC)=O)=C1)C4=CC=C(C=C4)F

Molecular Formula

C25H19FN2O5

Molecular Weight

446.43

References & Citations

[1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28 (10) :115435.