Microtubule inhibitor 6
Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1].
Product Specifications
CAS Number
2416338-64-0
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-inhibitor-6.html
Solubility
10 mM in DMSO
Smiles
COCC1=CC=C(O1)/C=C2NC(/C(NC\2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O
Molecular Formula
C24H19FN2O5
Molecular Weight
434.42
References & Citations
[1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28 (10) :115435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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