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Microtubule inhibitor 5

Microtubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability[1].

Product Specifications

CAS Number

2416338-55-9

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/microtubule-inhibitor-5.html

Solubility

10 mM in DMSO

Smiles

O=C1N/C(C(N/C1=C\C2=CC(OC3=CC=C(C=C3)F)=CC=C2)=O)=C\C4=CC=CO4

Molecular Formula

C22H15FN2O4

Molecular Weight

390.36

References & Citations

[1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28 (10) :115435.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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