Microtubule inhibitor 5
Microtubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability[1].
Product Specifications
CAS Number
2416338-55-9
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-inhibitor-5.html
Solubility
10 mM in DMSO
Smiles
O=C1N/C(C(N/C1=C\C2=CC(OC3=CC=C(C=C3)F)=CC=C2)=O)=C\C4=CC=CO4
Molecular Formula
C22H15FN2O4
Molecular Weight
390.36
References & Citations
[1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28 (10) :115435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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