Microtubule inhibitor 3
Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.
Product Specifications
CAS Number
1236141-96-0
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/microtubule-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=C(N=CN1)/C=C2NC(/C(NC\2=O)=C/C3=CC(C(C4=CC=C(C=C4)F)=O)=CC=C3)=O)C
Molecular Formula
C26H23FN4O3
Molecular Weight
458.48
References & Citations
[1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28 (10) :115435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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