HIV-1 inhibitor-39

HIV-1 inhibitor-39 (compound 3c) is a potent HIV-1 inhibitor with an EC50 of >112.88 µM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC50 of 15.75 µM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC50 of 112.9 µM[1].

Product Specifications

CAS Number

[2414099-82-2]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-39.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(S(=O)(C)=O)C=C1)CSC2=NN=C(N3C(C4=CC=CC(Cl)=C4)SCC3=O)S2

Molecular Formula

C20H17ClN4O4S4

Molecular Weight

541.09

References & Citations

[1]Buemi MR, et al. Inhibition of HIV-1 RT activity by a new series of 3- (1,3,4-thiadiazol-2-yl) thiazolidin-4-one derivatives. Bioorg Med Chem. 2020 Apr 15;28 (8) :115431.