hCAIX-IN-8
Product Specifications
UNSPSC Description
hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 μM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].
Target Antigen
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-8.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(/C=C/C(O)=O)=CC=C1OCC2=CN(N=N2)C3=CC([N+]([O-])=O)=CC=C3
Molecular Weight
396.35
References & Citations
[1]Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147722/hCAIX-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147722/
Clinical Information
No Development Reported
CAS Number
2414633-40-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
