CDK8-IN-6
CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer[1].
Product Specifications
CAS Number
2415156-27-1
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-6.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2
Molecular Formula
C26H37ClN2
Molecular Weight
413.04
References & Citations
[1]Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28 (10) :115461.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8
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