FGFR3-IN-3
Product Specifications
UNSPSC Description
FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].
Target Antigen
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr3-in-3.html
Solubility
10 mM in DMSO
Smiles
CCNS(=O)(C1=C(C=CC=C1)NC2=NC(NC3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)=NC=C2NC(C6=CC(OC)=CC(OC)=C6)=O)=O
Molecular Weight
759.92
References & Citations
[1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147715/FGFR3-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147715/
Clinical Information
No Development Reported
CAS Number
2428738-41-2
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