FGFR3-IN-2
FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].
Product Specifications
CAS Number
2428742-58-7
UNSPSC
12352005
Target
FGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr3-in-2.html
Solubility
10 mM in DMSO
Smiles
CCNS(=O)(C1=CC=CC=C1NC2=NC(NC3=CC=C(C(OCCN4CCOCC4)=C3)N5CCN(CC5)C)=NC=N2)=O
Molecular Formula
C28H39N9O4S
Molecular Weight
597.73
References & Citations
[1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28 (10) :115453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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