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FGFR3-IN-2

FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].

Product Specifications

CAS Number

2428742-58-7

UNSPSC

12352005

Target

FGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr3-in-2.html

Solubility

10 mM in DMSO

Smiles

CCNS(=O)(C1=CC=CC=C1NC2=NC(NC3=CC=C(C(OCCN4CCOCC4)=C3)N5CCN(CC5)C)=NC=N2)=O

Molecular Formula

C28H39N9O4S

Molecular Weight

597.73

References & Citations

[1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28 (10) :115453.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

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