Aurora kinase inhibitor-9
Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC50s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity[1].
Product Specifications
CAS Number
[2419107-09-6]
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurora-kinase-inhibitor-9.html
Solubility
10 mM in DMSO
Smiles
CCOC(C1=C(C2=C(C=C(C=C2N=C1)Cl)Cl)NC3=CC(S(=O)(NC)=O)=CC=C3)=O
Molecular Formula
C19H17Cl2N3O4S
Molecular Weight
454.33
References & Citations
[1]Al-Sanea MM, et al. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorg Med Chem. 2020 Jul 1;28 (13) :115525.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
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