FRα-IN-1

FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells[1].

Product Specifications

CAS Number

[2028296-64-0]

UNSPSC

12352005

Target

Antifolate

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/frα-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCCCC(N2)=CC3=C2N=C(N)NC3=O)C=C1)=O

Molecular Formula

C21H24N6O6

Molecular Weight

456.45

References & Citations

[1]Golani LK, et al. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorg Med Chem. 2020 Jun 15;28 (12) :115544.