C-Met-IN-11
C-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].
Product Specifications
CAS Number
1446324-05-5
UNSPSC
12352005
Target
C-Met/HGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-11.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=NC=CC(OC3=C(C=C(C=C3)NC4=C5C(C(C6=CC=C(C=C6)F)=CNC5=CC=N4)=O)F)=C2C=C1
Molecular Formula
C30H20F2N4O3
Molecular Weight
522.50
References & Citations
[1]Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28 (12) :115555.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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