MPO-IN-5
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
Product Specifications
CAS Number
2476764-11-9
UNSPSC
12352005
Target
Glutathione Peroxidase; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mpo-in-5.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
References & Citations
[1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO) . Bioorg Med Chem. 2020 Jun 15;28 (12) :115548.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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