Isoleucyl tRNA synthetase-IN-2
Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki, app of 114 nM[1].
Product Specifications
CAS Number
2494195-61-6
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/isoleucyl-trna-synthetase-in-2.html
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H]([C@H](OC1)COS(NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)O)[C@@H]1OCCN2C=C(C3=CC=CC=C3)N=N2
Molecular Formula
C22H33N5O8S
Molecular Weight
527.59
References & Citations
[1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28 (15) :115580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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