α-Synuclein inhibitor 7

α-Synuclein inhibitor 7 (compound 3gf) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.95 μM and inhibition ratio at 30 μM of 85.8%[1].

Product Specifications

CAS Number

2489813-04-7

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-7.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(O)=C(C(O)=C1)O)NC2=CC=C(C=C2)NC(C3=CC=C(C=C3F)F)=O

Molecular Formula

C20H14F2N2O5

Molecular Weight

400.33

References & Citations

[1]Chen L, et al. Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation. Bioorg Med Chem. 2020 Aug 1;28 (15) :115596.