α-Synuclein inhibitor 5
α-Synuclein inhibitor 5 (compound 4aa) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.22 μM and inhibition ratio at 30 μM of 94.3%[1].
Product Specifications
CAS Number
[2489813-11-6]
UNSPSC
12352005
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-synuclein-inhibitor-5.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)S(=O)(NC2=CC=C(C=C2)NC(C3=CC(O)=C(C(O)=C3)O)=O)=O
Molecular Formula
C20H18N2O6S
Molecular Weight
414.43
References & Citations
[1]Chen L, et al. Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation. Bioorg Med Chem. 2020 Aug 1;28 (15) :115596.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation
Curated Selection
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