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α-Synuclein inhibitor 5

α-Synuclein inhibitor 5 (compound 4aa) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC50 of 1.22 μM and inhibition ratio at 30 μM of 94.3%[1].

Product Specifications

CAS Number

[2489813-11-6]

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-5.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(C=C1)S(=O)(NC2=CC=C(C=C2)NC(C3=CC(O)=C(C(O)=C3)O)=O)=O

Molecular Formula

C20H18N2O6S

Molecular Weight

414.43

References & Citations

[1]Chen L, et al. Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation. Bioorg Med Chem. 2020 Aug 1;28 (15) :115596.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α-synuclein Aggregation

Curated Selection

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