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DHFR-IN-2

DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].

Product Specifications

CAS Number

331942-46-2

UNSPSC

12352005

Target

Antifolate

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(CNC2=CC=CC=C2)=CC=C1)O

Molecular Formula

C14H13NO2

Molecular Weight

227.26

References & Citations

[1]Kronenberger T, et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorg Med Chem. 2020 Aug 1;28 (15) :115600.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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