AChE/BChE/BACE-1-IN-2

AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1].

Product Specifications

CAS Number

[1877000-20-8]

UNSPSC

12352005

Target

Beta-secretase; Cholinesterase (ChE) ; ROS Kinase

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-bche-bace-1-in-2.html

Solubility

10 mM in DMSO

Smiles

FC1=CC(F)=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3

Molecular Formula

C18H20F2N2

Molecular Weight

302.36

References & Citations

[1]Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. Bioorg Med Chem. 2020 Nov 15;28 (22) :115721.