AChE/BChE/BACE-1-IN-1
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].
Product Specifications
CAS Number
1321361-13-0
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE) ; ROS Kinase
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-bace-1-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F
Molecular Formula
C19H21F3N2O
Molecular Weight
350.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Frequently Asked Questions
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