AChE/BChE/BACE-1-IN-1

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].

Product Specifications

CAS Number

[1321361-13-0]

UNSPSC

12352005

Target

Beta-secretase; Cholinesterase (ChE) ; ROS Kinase

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-bche-bace-1-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F

Molecular Formula

C19H21F3N2O

Molecular Weight

350.38

References & Citations

[1]Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. Bioorg Med Chem. 2020 Nov 15;28 (22) :115721.