GABAA receptor modulator-2
GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].
Product Specifications
CAS Number
2413850-54-9
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gabaa-receptor-modulator-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C2=CC=C(C=C2)F)=NO1)COC3=NC4=C(C=C3)CN(C(CS(C)(=O)=O)=O)CC4
Molecular Formula
C22H22FN3O5S
Molecular Weight
459.49
References & Citations
[1]Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65 (11) :7876-7895.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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