NAMPT degrader-1

NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].

Product Specifications

CAS Number

[3011778-39-2]

UNSPSC

12352005

Target

ATTECs; Autophagy; NAMPT

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nampt-degrader-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7

Molecular Formula

C56H68ClN9O5S2

Molecular Weight

1046.78

References & Citations

[1]Dong G, et al. Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT) . J Med Chem. 2022 Jun 9;65 (11) :7619-7628.