NAMPT degrader-1
Product Specifications
UNSPSC Description
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].
Target Antigen
ATTECs; Autophagy; NAMPT
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
Molecular Weight
1046.78
References & Citations
[1]Dong G, et al. Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT). J Med Chem. 2022 Jun 9;65(11):7619-7628.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147656/NAMPT-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147656/
Clinical Information
No Development Reported
CAS Number
3011778-39-2
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