Integrase-LEDGF/p75 allosteric inhibitor 1
Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].
Product Specifications
CAS Number
1431738-14-5
UNSPSC
12352005
Target
HIV Integrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/integrase-ledgf-p75-allosteric-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1C)C2=C(C(C3=CC=C4OCCCC4=C3C)=C(C(C)=C2NS(C)(=O)=O)C(C(O)=O)OC(C)(C)C)C
Molecular Formula
C33H41NO6S
Molecular Weight
579.75
References & Citations
[1]Sugiyama S, et al. Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold. Bioorg Med Chem. 2020 Sep 1;28 (17) :115643.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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