HIV-1 protease-IN-5

HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants[1].

Product Specifications

CAS Number

[2525173-96-8]

UNSPSC

12352005

Target

HIV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-protease-in-5.html

Solubility

10 mM in DMSO

Smiles

C[C@H](CN(S(=O)(C1=CC=C(C=C1)C(F)(F)F)=O)C[C@H]([C@@H](NC(C2=CC(O)=C(C=C2)O)=O)CC3=CC=CC=C3)O)O

Molecular Formula

C27H29F3N2O7S

Molecular Weight

582.59

References & Citations

[1]Zhu M, et al. Design and biological evaluation of novel HIV-1 protease inhibitors with isopropanol as P1' ligand to enhance binding with S1' subsite. Bioorg Med Chem. 2020 Aug 15;28 (16) :115623.