Cav 2.2/3.2 blocker 1
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC50 values of 78 μM and 80 μM against Cav2.2 and Cav3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS[1].
Product Specifications
CAS Number
[2987640-67-3]
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cav-2-2-3-2-blocker-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=CC=CC=C2CCC3=CC=CC=C31)C4=CC=C(OCCCN5CCOCC5)C=C4
Molecular Formula
C28H30N2O3
Molecular Weight
442.55
References & Citations
[1]Cardoso FC, et al. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorg Med Chem. 2020 Sep 15;28 (18) :115655.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
N-type calcium channel; T-type calcium channel
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