ATR-IN-15
ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].
Product Specifications
CAS Number
[2756665-52-6]
UNSPSC
12352005
Target
ATM/ATR; DNA-PK; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-15.html
Solubility
10 mM in DMSO
Smiles
CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[C@H](C)COCC4)C5=CC=NN5C
Molecular Formula
C19H22N8O
Molecular Weight
378.43
References & Citations
[1]Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; ATR; PI3K
Curated Selection
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