HIV-1 inhibitor-35

HIV-1 inhibitor-35 (compound 74) is a potent HIV-1 inhibitor with EC50s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC50 of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent[1].

Product Specifications

CAS Number

[2416971-32-7]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-35.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(CC1)C2=CN=C(C(Cl)=C2)Cl)NC3=NC=C(S3)Cl

Molecular Formula

C13H12Cl3N5OS

Molecular Weight

392.69

References & Citations

[1]Nguyen W, et al. Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents. Eur J Med Chem. 2020;195:112254.