Keap1-Nrf2-IN-10

Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice[1].

Product Specifications

CAS Number

[2445349-54-0]

UNSPSC

12352005

Target

Quinone Reductase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/keap1-nrf2-in-10.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(NC(CSC2=NC3=C(C=C(C=C3C(N2C4=CC=C(C=C4)S(N)(=O)=O)=O)I)I)=O)=CC(OC)=C1OC

Molecular Formula

C25H22I2N4O7S2

Molecular Weight

808.40

References & Citations

[1]Soliman AM, et al. Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4 (3H) -ones carrying a sulfonamide moiety. Eur J Med Chem. 2020 Aug 15;200:112467.