A1AR antagonist 6
A1AR antagonist 6 (compound 15) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 6.38 and a pKi of 7.13[1].
Product Specifications
CAS Number
[329693-22-3]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a1ar-antagonist-6.html
Purity
98.13
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N=C2CCCCC2=C1C3=CC=C4OCOC4=C3)N
Molecular Formula
C17H15N3O2
Molecular Weight
293.32
References & Citations
[1]Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR)
Available Sizes
Curated Selection
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