A1AR antagonist 5
A1AR antagonist 5 (compound 20) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.83 and a pKi of 6.11[1].
Product Specifications
CAS Number
[1030509-01-3]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a1ar-antagonist-5.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(N2CCCC2)=NC3=C1C(C4=CC=C(C=C4)Cl)=CC=N3
Molecular Formula
C17H15ClN4O
Molecular Weight
326.78
References & Citations
[1]Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR)
Curated Selection
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