A1AR antagonist 4
A1AR antagonist 4 (compound 22) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.51 and a pKi of 6.29[1].
Product Specifications
CAS Number
1031993-35-7
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a1ar-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)C(NC2=C(NC3=CC=C(C=C32)C)C(NC4CCCC4)=O)=O
Molecular Formula
C23H25N3O2
Molecular Weight
375.46
References & Citations
[1]Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR)
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