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Antileishmanial agent-9

Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC50 = 40.1 μM) [1].

Product Specifications

CAS Number

2477608-91-4

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-9.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)/C=C/C1=CC=C(OC(C2=CC=C(OC)C=C2)C3C)C3=C1

Molecular Formula

C23H26O4

Molecular Weight

366.45

References & Citations

[1]Bernal FA, et al. (±) -trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis. Eur J Med Chem. 2020;205:112493.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Leishmania

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