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Antileishmanial agent-8

Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM) [1].

Product Specifications

CAS Number

2477608-96-9

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-8.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C/C1=CC=C(OC(C2=CC=C(O)C=C2)C3C)C3=C1

Molecular Formula

C18H16O4

Molecular Weight

296.32

References & Citations

[1]Bernal FA, et al. (±) -trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis. Eur J Med Chem. 2020;205:112493.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Leishmania

Frequently Asked Questions

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