RORγt inverse agonist 30
Product Specifications
UNSPSC Description
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-30.html
Solubility
10 mM in DMSO
Smiles
CC(N1CCN(CC1)C2=CC=C(C=C2)CN(S(=O)(CC3=CC=CC=C3)=O)C4CCC4)=O
Molecular Weight
441.59
References & Citations
[1]Nannan Sun, et al. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. Eur J Med Chem. 2020 Feb 1;187:111984.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147533/RORγt-inverse-agonist-30-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147533/
Clinical Information
No Development Reported
CAS Number
1445901-41-6
Curated Selection
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