MGluR2 modulator 3
MGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice[1].
Product Specifications
CAS Number
1004614-58-7
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mglur2-modulator-3.html
Solubility
10 mM in DMSO
Smiles
CN1C2=CC=CC=C2N=C1CN3CCC(CC3)C4=CC=CC=C4OC
Molecular Formula
C21H25N3O
Molecular Weight
335.44
References & Citations
[1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020;186:111881.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2
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