MGluR2 modulator 3

MGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice[1].

Product Specifications

CAS Number

[1004614-58-7]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mglur2-modulator-3.html

Solubility

10 mM in DMSO

Smiles

CN1C2=CC=CC=C2N=C1CN3CCC(CC3)C4=CC=CC=C4OC

Molecular Formula

C21H25N3O

Molecular Weight

335.44

References & Citations

[1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020;186:111881.