RM-581
RM-581, an aminosteroid derivative, is an endoplasmic reticulum stress (ERS) inducer. RM-581 induces cancer cells apoptosis. RM-581 can be used for the study of pancreatic, prostate and breast cancers[1][2][3].
Product Specifications
CAS Number
2086809-59-6
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rm-581.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(N5CCN(CC5)C([C@H]6N(CCC6)C(C7=NC8=C(C=CC=C8)C=C7)=O)=O)=C(OC)C=C4CC3
Molecular Formula
C40H46N4O4
Molecular Weight
646.82
References & Citations
[1]René Maltais, et al. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. Eur J Med Chem. 2020 Feb 15;188:111990.|[2]Donald Poirier, et al. Abstract 5639: A potent aminosteroid (RM-581) that inhibits orally in mice the tumor growth in an orthotopic xenograft pancreatic cancer model. Cancer Res (2025) 85 (8_Supplement_1) : 5639.|[3]Donald Poirier, et al. Abstract 5748: Metabolites of the orally potent anticancer agent and endoplasmic reticulum stress inducer RM-581. Cancer Res (2025) 85 (8_Supplement_1) : 5748.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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