P38-α MAPK-IN-5
P38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
Product Specifications
CAS Number
1443242-46-3
UNSPSC
12352005
Hazard Statement
H272
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p38-α-mapk-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C
Molecular Formula
C37H49N11O2
Molecular Weight
679.86
Precautions
P210-P220-P280-P370+P378-P501
References & Citations
[1]Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65 (10) :7170-7192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; p38β; p38γ; p38δ
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