TRβ agonist 3
TRβ agonist 3 (Compound 3) is a potent agonist of TRβ. TRβ agonist 3 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 3 is a new potential TRβ-selective thyromimetics[1].
Product Specifications
CAS Number
[2411099-46-0]
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/trβ-agonist-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(C=C2)N
Molecular Formula
C20H25NO3
Molecular Weight
327.42
References & Citations
[1]Runfola M, et al. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. Eur J Med Chem. 2020 Feb 15;188:112006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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