TRβ agonist 3

TRβ agonist 3 (Compound 3) is a potent agonist of TRβ. TRβ agonist 3 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 3 is a new potential TRβ-selective thyromimetics[1].

Product Specifications

CAS Number

[2411099-46-0]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/trβ-agonist-3.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(C=C2)N

Molecular Formula

C20H25NO3

Molecular Weight

327.42

References & Citations

[1]Runfola M, et al. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. Eur J Med Chem. 2020 Feb 15;188:112006.