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Zifcasiran (sodium)

Zifcasiran (ADS-007) sodium is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC) . Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation[1].

Product Specifications

CAS Number

2437257-12-8

Product Name Alternative

ADS-007 (sodium) ; ARO HIF2 (sodium)

UNSPSC

12352208

Target

HIF/HIF Prolyl-Hydroxylase; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zifcasiran-sodium.html

Solubility

10 mM in H2O

Smiles

[Zifcasiran(sodium)]

Molecular Formula

C737H929F20N211Na52O349P43S8

Molecular Weight

21491.26

References & Citations

[1]Brugarolas J, et al. A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2024 Jun 3;30 (11) :2402-2411.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Frequently Asked Questions

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