Dopamine D4 receptor antagonist-1

Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1].

Product Specifications

CAS Number

[444724-92-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dopamine-d4-receptor-antagonist-1.html

Purity

98.59

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

ClC1=CC(N2CCN(CC2)CC3=NC4=C(N3)C=CC=C4)=CC=C1

Molecular Formula

C18H19ClN4

Molecular Weight

326.82

Precautions

H315, H319, H320

References & Citations

[1]Pugsley TA, et al. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26 (2) :219-26.