hiCE inhibitor-1
Product Specifications
UNSPSC Description
hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].
Target Antigen
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hice-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(S(=O)(NC2=CC=C(NS(=O)(C3=CC=C(Cl)C=C3)=O)C=C2)=O)C=C1
Molecular Weight
457.35
References & Citations
[1]Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147388/hiCE-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147388/
Clinical Information
No Development Reported
CAS Number
2654-68-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal Synphilin-1 Antibody [DyLight 594]](https://cdn.genprice.uk/genprice/genprice2.png)
