HiCE inhibitor-1

HiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562) -induced diarrhoea[1].

Product Specifications

CAS Number

[2654-68-4]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hice-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(S(=O)(NC2=CC=C(NS(=O)(C3=CC=C(Cl)C=C3)=O)C=C2)=O)C=C1

Molecular Formula

C18H14Cl2N2O4S2

Molecular Weight

457.35

References & Citations

[1]Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65 (6) :1336-43.