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Bromodomain inhibitor-10

Bromodomain inhibitor-10 (compound 128) is a potent bromodomain inhibitor with Kds of 15.0, 2500 nM for BRD4-1 and BRD4-2, respectively. Bromodomain inhibitor-10 inhibits the production of IL12p40[1].

Product Specifications

CAS Number

1870849-58-3

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bromodomain-inhibitor-10.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(NC2=C1C=C(NC(C3=C(N4CCOCC4)N=CC=C3)=O)C=C2)=O

Molecular Formula

C20H20N4O3

Molecular Weight

364.40

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Jimmi GERNER SEITZBERG, et al. Compounds active towards bromodomains. WO2016016316A1

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD4

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